Longevity

Longevity isn’t just about living longer—it’s about thriving with vitality at every age.
Modern science reveals that aging is deeply influenced by cellular wear, DNA damage, and declining energy production. Cibdol’s longevity range targets these root causes with clinically studied ingredients to help you maintain peak physical and mental function for years to come.

What Is Longevity?

Longevity refers to extending healthspan—the number of years we live in good health—rather than just lifespan. Modern research shows that aging is driven by cellular damage accumulation, leading to:

• Toxic buildup (impaired autophagy)

• Declining energy production (mitochondrial dysfunction)

• Chronic inflammation & stress damage

The goal of longevity science is to slow, stop, or reverse these processes using nutrition, lifestyle, and targeted supplementation.

What Is Autophagy?

The Body’s Cellular Cleanup System

Autophagy (Greek for "self-eating") is the process where cells break down and recycle damaged components, including:

• Misfolded proteins (linked to Alzheimer’s & Parkinson’s)

• Dysfunctional mitochondria (leading to fatigue)

• Intracellular pathogens (viruses, bacteria)

Why Autophagy Declines with Age

• After 30, autophagy efficiency drops by ~1% per year (Nature, 2018).

• Impaired autophagy is linked to cancer, neurodegeneration, and metabolic disease.

How to Activate Autophagy Naturally

Autophagy, the body’s cellular cleanup process, can be naturally enhanced through several scientifically supported methods:

• Fasting – By lowering mTOR (a nutrient-sensing pathway) and activating AMPK (an energy regulator), fasting triggers autophagy. A 16-hour intermittent fast is a practical way to stimulate this process.

• Exercise – Physical activity, especially high-intensity interval training (HIIT), increases TFEB, a gene responsible for autophagy activation, promoting cellular repair and renewal.

• Spermidine – This natural compound binds to lipid membranes, directly inducing autophagy. Dietary sources like wheat germ and aged cheese provide spermidine, but supplementation ensures optimal levels.

• Resveratrol – Found in red wine and Japanese knotweed, resveratrol activates SIRT1, a key regulator of autophagy and longevity pathways.

Combining these methods—such as intermittent fasting, regular exercise, and targeted supplementation—can maximize autophagy for better cellular health and longevity.

What Is Spermidine?

Spermidine is a natural polyamine compound found in foods like wheat germ, aged cheese, and mushrooms. It plays a critical role in:

• Cell growth and proliferation

• DNA stability

• Protein function regulation

As we age, spermidine levels decline by ~60% after age 50 (Aging Cell, 2021), accelerating cellular dysfunction.

How Does Spermidine Work for Longevity?

1. Induces Autophagy

   • Spermidine activates ATG5 and LC3 proteins, triggering autophagy—the body’s process of recycling damaged cells and organelles (Nature Cell Biology, 2018).

   • This "cellular spring cleaning" removes toxic debris linked to Alzheimer’s, heart disease, and sarcopenia.

2. Protects Mitochondria

   • Reduces oxidative stress in mitochondria by upregulating antioxidant enzymes (SOD, catalase).

   • Preserves ATP production capacity, critical for muscle and brain function.

3. Cardio- & Neuroprotective

   • Lowers systolic blood pressure by 10 mmHg in hypertensive patients (Journal of Hypertension, 2020).

   • Crosses the blood-brain barrier to reduce tau protein tangles (associated with dementia).

Cibdol’s Formula:

• Dose: 1mg/mL liquid extract (equivalent to 100g wheat germ daily).

• Synergists: Paired with zinc for enhanced absorption.

What is Mitochondrial Energy (NAD+ Support)

Mitochondria are often called the "power plants" of our cells because they generate ATP—the energy currency that fuels everything from muscle movement to brain function. As we age, however, our mitochondria become less efficient, leading to fatigue, slower recovery, and accelerated aging. One of the main reasons for this decline is the drop in NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme that supports mitochondrial function.

By age 50, NAD+ levels can decrease by as much as 50% (Cell Metabolism, 2020). This decline impairs energy production, weakens cellular repair mechanisms, and contributes to age-related conditions like muscle loss, cognitive decline, and metabolic disorders. Additionally, mitochondrial DNA accumulates damage over time, further reducing their ability to generate energy efficiently.

Can you boost Mitochondrial Energy  naturally?

Fortunately, research shows that boosting NAD+ levels can help restore mitochondrial function and counteract age-related decline. Compounds like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) act as direct precursors to NAD+, effectively replenishing cellular energy. Studies have demonstrated that NAD+ support can enhance endurance, improve cognitive function, and even promote DNA repair—making it a cornerstone of longevity science.

By maintaining healthy NAD+ levels through targeted supplementation and lifestyle choices (such as exercise and calorie restriction), we can help sustain mitochondrial vitality, delay aging, and support overall well-being well into later life.

What Is NMN?

NMN: The NAD+ Booster for Cellular Vitality

Building on the crucial role of mitochondrial energy and NAD+ in longevity, Nicotinamide Mononucleotide (NMN) emerges as one of the most effective ways to combat age-related decline. As a direct precursor to NAD+, NMN helps replenish this vital coenzyme—levels of which drop by 50% by age 50 (Cell Metabolism, 2020). But how exactly does it work to promote longevity?

How NMN Supports Youthful Function

1. Revitalizes NAD+ Levels
   NMN converts into NAD+ through the salvage pathway, acting like fuel for sirtuins (SIRT1-7)—a family of proteins often called "longevity genes." These sirtuins play a pivotal role in:

   • DNA repair, protecting against mutations.

   • Metabolic regulation, helping maintain healthy blood sugar and cholesterol levels.

2. Supercharges Mitochondria
   By restoring NAD+, NMN enhances mitochondrial efficiency, leading to:

   • 30% better oxygen utilization in aging muscles (Science, 2021), improving endurance and reducing fatigue.

   • Clearance of senescent "zombie cells" (which accelerate aging) via AMPK pathway activation.

3. Protects Brain Health
   Preclinical studies show NMN:

   • Increases cerebral blood flow, supporting memory and focus.

   • Stimulates neurogenesis (new brain cell growth) (Nature Communications, 2022), potentially guarding against cognitive decline.

Why NMN Stands Out

Unlike other NAD+ boosters, NMN is more stable and bioavailable, making it a preferred choice for longevity enthusiasts. Combined with resveratrol (which activates sirtuins) and exercise (which further boosts NAD+), it creates a powerful synergy for sustaining energy and vitality.

The Takeaway: NMN isn’t just about adding years to life—it’s about adding life to years by keeping cells functioning at their peak.

Cibdol’s Formula:

• Dose: 250mg enteric-coated capsules (optimal for bioavailability).

• Stack Suggestion: Combine with resveratrol to amplify SIRT1 activation.

What Is Resveratrol?

A polyphenol found in red wine and Japanese knotweed, known for activating longevity genes.

How Does Resveratrol Work for Longevity?

1. Activates Sirtuins

   • Binds directly to SIRT1, mimicking calorie restriction effects (Science, 2003).

   • Extends lifespan in yeast/nematodes by 30%.

2. Anti-Inflammatory Effects

   • Inhibits NF-kB (master inflammation regulator).

   • Protects vascular endothelial cells, reducing arterial stiffness.

3. Synergy with NMN

   • Resveratrol potentiates NAD+ by inhibiting CD38 (an NAD+-consuming enzyme).

Cibdol’s Formula:

• 98% Trans-Resveratrol (most bioactive form) + quercetin for absorption.

What Is Ashwagandha?

An adaptogen used in Ayurveda for stress resilience and vitality.

How Does Ashwagandha Work for Longevity?

1. Reduces Cortisol

   • Lowers cortisol by 28% in chronic stress (Indian Journal of Psychological Medicine, 2019).

   • High cortisol accelerates telomere shortening (a biomarker of aging).

2. Boosts Mitochondrial Biogenesis

   • Upregulates PGC-1α, increasing mitochondrial density in muscle cells.

3. Thyroid Support

   • Normalizes T3/T4 levels in subclinical hypothyroidism (Journal of Alternative Medicine, 2018).

Cibdol’s Formula:

• Standardized to 5% withanolides (clinically effective dose).

Why These Ingredients Work Together

Aging accelerates when:

1. NAD+ levels drop → Slower metabolism, fatigue.

2. Autophagy declines → Toxic cellular waste accumulates.

3. Inflammation rises → DNA damage speeds up.

Cibdol’s formulas address all three pathways:

• NMN replenishes NAD+.

• Spermidine cleans damaged cells.

• Ashwagandha/Reishi reduce inflammatory triggers.