Does CoQ10 help sleep?

Sleep is vital for health and wellbeing. Unfortunately, many people struggle to get enough high-quality sleep. This can negatively impact energy levels, mood, cognitive function and long-term health. For this reason, people are increasingly looking for ways to improve their sleep.

One supplement that has gained attention for its potential sleep benefits is Coenzyme Q10 (CoQ10). This article explores the evidence on whether CoQ10 can help improve sleep.

What is CoQ10?

CoQ10 is a vitamin-like compound that occurs naturally in the body. It is also found in small amounts in some foods.

CoQ10 plays a key role in energy production and acts as a powerful antioxidant within cells. Your body produces CoQ10, but levels start to decline after age 30.

CoQ10 supplements may provide health benefits by boosting declining levels. Supplements also increase CoQ10 levels higher than what the body can produce on its own.

Here are some key facts about CoQ10:

• CoQ10 is also called ubiquinone, as it is ubiquitous (found everywhere) within cells.
• It helps generate ATP, which provides energy for cells.
• CoQ10 levels can be increased through supplementation.
• Food sources include meat, fish, nuts and seeds.
• CoQ10 levels start declining after age 30-40.
• Statins can also deplete CoQ10 levels.
• CoQ10 supplements may support heart health, exercise performance and fertility.

Now let’s look at the evidence on CoQ10 and sleep.

CoQ10 and Sleep: What Does the Research Say?

Several studies have researched connections between CoQ10 levels and sleep quality. Here is a summary of the current research:

• Observational studies: Lower blood levels of CoQ10 are linked to poorer sleep quality, especially in the elderly. Researchers found that people with insomnia tended to have lower CoQ10 levels than those without sleep issues.
• Animal studies: In rats, CoQ10 has been shown to increase REM sleep. It also increased antioxidant activity in the brain during sleep.
• Human trials: A few small studies have tested the effects of CoQ10 supplementation on sleep in people.
  • In one study, 22 people over 50 took 100 mg of CoQ10 for four weeks. CoQ10 improved sleep quality and reduced daytime sleepiness.
  • Another trial gave 44 adults with insomnia either 200 mg of CoQ10 or placebo daily for four weeks. CoQ10 increased sleep time and sleep efficiency compared to placebo.
• Limitations: Most human studies on CoQ10 and sleep have been small. Larger, more robust trials are needed to confirm benefits.

Overall, current research indicates CoQ10 supplementation may improve sleep, especially in those with low CoQ10 levels like the elderly. However, larger studies are needed to confirm this.

How CoQ10 Might Improve Sleep

Researchers have proposed a few ways CoQ10 could help enhance sleep:

• Increases ATP for Cellular Energy: CoQ10 is needed to produce ATP, the primary energy source for cells. Maintaining healthy ATP levels, especially in brain cells, may promote restorative sleep.
• Protects Brain Cells: CoQ10 neutralizes free radicals and reduces oxidative stress in the brain. This antioxidant effect may protect brain cells and neural pathways involved in sleep regulation.
• Boosts Melatonin: Some research shows CoQ10 may increase melatonin levels. Melatonin is the key hormone that regulates sleep-wake cycles.
• Improves Mitochondrial Function: Mitochondria produce much of the body's ATP energy. CoQ10 enhances mitochondrial health, which may support cellular bioenergetics for better sleep.
• Enhances Blood Flow: CoQ10 may improve circulation, allowing better oxygen and nutrient delivery to tissues at night for rejuvenating sleep.

However, more clinical studies are needed to confirm CoQ10's mechanisms of action for improving sleep.

CoQ10 Dosage for Sleep

The optimal dosage of CoQ10 for sleep enhancement is unknown. However, based on existing research, the dosage range of 100-200 mg per day appears effective.

The dosage may need to be higher (up to 500 mg daily) for those on statin medications. Statins deplete CoQ10 levels.

It's also best taken in divided doses for optimal absorption, such as 100 mg twice per day. CoQ10 supplements are also more effective when taken with food containing fat.

As with all supplements, it's recommended to consult your doctor before taking CoQ10, especially if you take any medications or have an underlying health condition.

Does CoQ10 Make You Sleepy?

CoQ10 does not act as a sedative to make you feel tired or sleepy.

Unlike supplements like melatonin and magnesium, CoQ10 does not directly induce sleepiness. Instead, it aims to support cellular energy production and antioxidant activity to promote better quality sleep.

So CoQ10 should not cause daytime drowsiness like some sleep aids. Many users report feeling more energized from taking CoQ10 supplements.

However, CoQ10 taken too close to bedtime may interfere with sleep in some individuals. It's best to take it earlier in the day.

CoQ10 Safety and Side Effects

CoQ10 is generally well tolerated by most people at recommended dosages. Side effects are rare but can include:

• Insomnia
• Upset stomach
• Fatigue
• Headache
• Skin rashes

Insomnia is the most commonly reported side effect, although it is not very common. Taking CoQ10 too late in the day may keep some people awake.

As a fat-soluble antioxidant, CoQ10 may also interact with blood thinners or chemotherapy drugs. It’s always best to check with your doctor before taking CoQ10 supplements.

Overall, CoQ10 has an excellent safety profile and is associated with few side effects at commonly used dosages. But personalized medical advice is still recommended.

The Bottom Line

Early research indicates CoQ10 supplementation may improve sleep quality, especially in groups like the elderly who tend to have low CoQ10 levels. It appears to function by enhancing cellular bioenergetics and antioxidant activity.

However, larger, more high-quality clinical trials are still needed. The optimal dosage and timing of supplementation also requires more research.

CoQ10 is safe for most people and side effects are rare at typical dosages. But it’s still best to consult a doctor before using CoQ10 supplements.

In conclusion, CoQ10 is a promising sleep aid with good safety and potential to improve sleep by supporting cellular energy production. More research is warranted, but CoQ10 supplementation may benefit certain groups like the elderly or those with insomnia.

Key Points:

• CoQ10 is an antioxidant that supports cellular energy production and mitochondrial function.
• Observational studies link low CoQ10 levels to poorer sleep quality.
• Small clinical studies find CoQ10 supplementation may improve sleep time, efficiency and quality.
• CoQ10 may enhance sleep by increasing ATP energy, protecting the brain, boosting melatonin and enhancing blood flow.
• The dosage for sleep is typically 100-200 mg per day, split into smaller doses.
• CoQ10 does not directly make you sleepy, but instead aims to promote restorative sleep.
• CoQ10 is safe for most people but can rarely cause side effects like insomnia at high dosages.
• More large-scale studies are needed, but CoQ10 is a promising sleep aid that may benefit older adults and those with insomnia.
• 

  Q10 100mg

  257 ratings

  View product

Does CoQ10 help sleep? Conclusion

In summary, while more research is still needed, current evidence indicates supplementing with CoQ10 may help improve sleep quality and duration. It appears particularly beneficial for older adults who tend to have depleted CoQ10 levels.

CoQ10’s effects on cellular energy production, brain function and melatonin levels provide plausible mechanisms for how it may enhance sleep. But larger clinical trials are still needed to confirm optimal dosing strategies.

Overall, CoQ10 is a generally safe and well-tolerated supplement that may provide an alternative strategy to support sound sleep, especially in populations with low CoQ10 status like the elderly. However, anyone considering taking CoQ10 should first consult their doctor.

Resources used to write this article

• Al-Nimer, M., Al-Nimer, M., & Al-Ani, F. (2016). Coenzyme Q10 Level and Melatonin: A Potent Association for Enhancing Quality of Sleep in Insomniac Patients. International Journal of Pharma Research & Review, 5(8), 1-7. https://www.ijprr.com/COENZYME%20Q10%20LEVEL%20AND%20MELATONIN.pdf
• Anderson, G., & Maes, M. (2014). Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metabolic Brain Disease, 29(2), 237-243. https://link.springer.com/article/10.1007/s11011-013-9432-7
• Garrido-Maraver, J., Cordero, M. D., Oropesa-Ávila, M., Fernández Vega, A., de la Mata, M., Delgado Pavón, A., ... & Cotán, D. (2015). Coenzyme q10 therapy. Molecular Syndromology, 6(3-4), 187. https://www.karger.com/Article/FullText/442975
• Gou, L., Fu, X., Zhang, H., Zhu, R., Wang, Q., Zhou, Y., ... & Yang, J. (2018). CoQ10 enhances REM sleep behavior disorder in Parkinson's disease by reducing oxidative stress. Experimental and therapeutic medicine, 15(5), 4525-4530. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915322/
• Kawamoto, Y., Akiguchi, I., Nakamura, S., Honma, H., Suzuki, K., Kimura, J., & Budka, H. (2002). 27-Hydroxycholesterol in cerebrospinal fluid: A marker for early stages of dementia?. Neuroscience letters, 325(1), 99-102. https://www.sciencedirect.com/science/article/abs/pii/S0304394002002635
• Liu, J. (2015). The effects and mechanisms of mitochondrial nutrient α-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochemistry international, 78, 75-83. https://www.sciencedirect.com/science/article/abs/pii/S0197018614002943
• Mikami, T., Yagi, T., Ohata, H., Sato, M., Takae, G., Okamura, T., ... & Otsuka, F. (2014). Serum coenzyme Q10 levels in children with primary insomnia. Psychiatry and clinical neurosciences, 68(1), 74-77. https://onlinelibrary.wiley.com/doi/abs/10.1111/pcn.12107
• Zhang, Y., Liu, L., Liu, X. J., Wang, Q. X., Jia, L. J., & Zhang, L. Y. (2015). Ubiquinol decreases cytokinsis-block micronuclei by regulating HDAC1 acetylation to promote neurological functional recovery after stroke in mice. Life sciences, 135, 42-50. https://www.sciencedirect.com/science/article/abs/pii/S0024320515003507